Figure 3

Dynamic changes in NMDARs in maturing adult-generated GCs. (A) The 10-90% rise time of NMDAR-mediated EPSCs became shorter with maturation (class 3 vs class 5; *P < 0.05) (class 3: five slices, five mice; class 4: nine slices, eight mice; class 5: four slices, four mice). (B) The decay time constant of NMDAR-mediated EPSCs was much lower in class 4 than in class 3 cells (class 3 versus class 4; *P < 0.05) (class 3: four slices, four mice; class 4: seven slices, six mice; class 5: four slices, four mice). (C) Peak-scaled variance-mean current for NMDAR-mediated EPSCs. The gray line was fitted linearly to the first 25% of the data points and used to estimate the weighted mean single open NMDAR channel conductance. (D) Fluctuation analysis showed an increase in NMDAR channel conductance during maturation (class 3 versus class 5; *P < 0.05) (class 3: four slices, four mice; class 4: eight slices, seven mice; class 5: four slices, four mice).