SD Plotted Against Graph Metrics. Each graph is generated by calculating System Difference and a graph metric in 24,000 random, weakly connected, normalized networks (n = 11). We sampled from graphs with degrees ranging from 1 to n-1, in steps of one such that the normalized graphs would only have one weight value (see Methods: System Difference comparisons with graph theory metrics (Figure 2) and 2003 Phi. Comparisons with Graph Variables'). The lines plotted on the graphs are the best fits for the second-degree polynomials of SD. SD is plotted against A) maximum degree, B) density, C) omega, D) average path length, E) motif number (size three) and F) motif number (size four).